The TASPPI project has the following vacancies in several leading biochemical research groups and companies in Europe.
ESR Position 06
PhD fellowship in control of the human kinome and autophagy by the docking of 14-3-3 proteins onto phosphoproteins
- elucidate how the sets of sister 2R-ohnologues that regulate autophagy are controlled by phosphorylation and 14-3-3 proteins;
- study a.o. the protein kinases ULK1 and ULK2 that signal to activate autophagy when cells are deprived of nutrients, and ATG9A and ATG9B, transmembrane proteins that help organise autophagosome structures;
- investigate how autophagy is influenced by small-molecules that disrupt or stabilise 14-3-3–phosphoprotein interactions;
- use cell-based biochemical approaches, phosphoproteomics and state-of-the-art microscopy.